WHAT IS PHASE ANGLE? Advacement in Bioenergy Metrics in Regenerative Medicine

Authored by: Dr. Leslie Valle-Montoya

PHASE ANGLE is a measurement used in bioelectrical impedance analysis (BIA)—a technology that sends a small, safe electrical signal through the body to learn about your health. The phase angle tells us how well your cells are functioning.  Your cells are like tiny batteries. A higher phase angle usually means your cells are healthy, strong, and holding their shape well—like fresh grapes. A lower phase angle may suggest weaker or damaged cells—like dried-up raisins. This number can help doctors or wellness professionals understand your body’s overall condition, hydration, and cellular health in our health span.  It’s often used in wellness, sports, and medical settings to track changes, especially during aging, illness, or nutritional programs.

Through the clinical work and mentorship of Dr. Robert Bard (BardDiagnostics NYC) and his recent presentation at the AIUM World Converence, advanced ultrasound systems can reveal the health of tissues in the present moment by measuring health and longevity through carotid artery ultrasound. This test looks at the major arteries in your neck that supply blood to your brain. It can measure how thick or stiff the artery walls are, which tells us how healthy your blood vessels are and how much plaque might be building up. Thinner, more flexible arteries mean better circulation and a lower risk of heart disease and stroke.

Together, phase angle and carotid ultrasound give a deeper picture of your internal health—from your cells to your circulation—and help guide wellness plans that support long-term vitality and longevity.

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Phase Angle: The Impact of Regenerative Therapies on Cellular Health

Key Takeaways

● Phase angle has emerged as a useful marker for assessing health risks, including morbidity and mortality, across a range of clinical scenarios. In this study, 22 participants—some healthy and others managing chronic conditions—were included.

● The findings provide average phase angle values for both men and women, offering insight into how these values vary by sex.

● Phase angle tends to increase steadily from early childhood through adolescence, to stabilize between ages 19 and 48, and then gradually to decline with age.

● These reference values can be a valuable tool for evaluating an individual's health status in a clinical setting.

Abstract
This study investigates the effects of regenerative therapies on cellular health and function using BioImpedance and Phase Angle Analysis. A pre-post intervention design was implemented, assessing phase angle as a marker of cellular integrity before and after treatment. Our findings demonstrate a statistically significant increase in phase angle, suggesting improved cell membrane function and overall vitality.

Introduction
Phase angle, derived from bioelectrical impedance analysis (BIA), is gaining recognition as a meaningful indicator of overall health. It reflects the relationship between resistance (R) and reactance (Xc) in body tissues. Lower phase angle values have been linked to cellular stress, membrane dysfunction, and impaired tissue integrity. Factors such as chronic illness, inflammation, malnutrition, and poor lifestyle habits can negatively impact the body’s electrical properties, which are captured in the phase angle. 

Recent studies show that individuals with chronic or acute illness often have reduced phase angle values, potentially indicating accelerated aging and diminished cellular regeneration. Because the phase angle is influenced by cell membrane integrity, cell size, and overall tissue health, having baseline reference values is essential for identifying deviations that might signal underlying health issues.

This study highlights the importance of understanding phase angle across different life stages. As anti-aging and wellness trends continue to grow, phase angle offers a promising, non-invasive window into cellular vitality and the aging process. Methods Study Design This was a single-group, pre-post intervention study conducted at the Santa Barbara Longevity Center. The goal was to assess the effects of a comprehensive cellular regeneration program on physiological markers of health and vitality. Participants underwent testing before and after the  Intervention to measure changes in autonomic function and cellular health.

Assessments
Two primary assessments were used to evaluate outcomes:

● Heart Rate Variability (HRV): Non-invasive HRV testing was used to assess autonomic nervous system balance and stress resilience.

● Bioelectrical Impedance Analysis (BIA): Phase angle was calculated as a marker of cellular integrity and vitality, based on resistance and reactance values. Both HRV and bioimpedance assessments were performed prior to the first session and again after completion of the full program.

Intervention Protocol
Each participant received a series of eight sessions over the course of four weeks. The program included the following therapies at each session:

● Ondamed Frequency Therapy: A bioenergetic treatment using pulsed electromagnetic fields to modulate cellular communication and support tissue regeneration.

● H-Wave Therapy: A form of electrotherapy designed to enhance blood flow, reduce inflammation, and stimulate lymphatic drainage and muscle recovery.

● Red Light Therapy: Low-level light therapy aimed at stimulating mitochondrial function, promoting cellular repair, and enhancing skin and tissue health.

● Infrared Sauna & Cold Plunge: A contrast therapy combining heat and cold exposure to support detoxification, reduce systemic inflammation, and improve circulation and recovery.

All sessions were conducted in a controlled wellness setting and overseen by trained practitioners. Participants were advised to maintain their usual diet and activity levels throughout the study period.

Measurements
Primary outcome measure: Phase Angle (PA) assessed before and after intervention using BioImpedance Analysis. Statistical analysis: Paired t-tests were used to determine significant changes, with a 95% confidence interval (CI) computed for phase angle pre- and post-intervention.

Results
Pre-Post Analysis

● Mean Phase Angle Before Treatment: 6.28 (95% CI: 5.71 – 6.84)

● Mean Phase Angle After Treatment: 6.86 (95% CI: 6.32 – 7.40)

● T-Statistic: -3.39

● P-Value: 0.0037

A statistically significant increase in phase angle was observed, indicating enhanced cellular membrane integrity and metabolic efficiency.

Discussion
The results of this study indicate that the combined use of frequency-based, circulatory, and metabolic-enhancing therapies can lead to measurable improvements in cellular health, as evidenced by a consistent increase in phase angle values among participants. Phase angle is recognized as a reliable marker of cell membrane integrity and intracellular hydration—both of which are essential indicators of biological vitality and resilience. An upward shift in this value suggests enhanced membrane stability, improved cellular function, and better overall physiological status.

Notably, several participants experienced remarkable improvements over the four-week intervention period:

● Subject 1: Phase angle increased from 5.4 to 6.6

● Subject 2: Phase angle increased from 6.0 to 6.9

● Subject 3: Phase angle increased from 6.5 to 8.0

● Subject 4: Phase angle increased from 4.4 to 5.2

These changes are particularly significant given how challenging it is to raise phase angle in such a short timeframe. In clinical settings, even small increases in phase angle are considered meaningful, making these improvements—some exceeding 1.0 or even 1.5 units—especially noteworthy. These outcomes suggest a strong regenerative effect from the combination of therapies delivered during the study.

The interventions likely worked synergistically to support cellular function from multiple angles. Ondamed Frequency Therapy may have restored bioenergetic balance and enhanced intercellular communication. H-Wave Therapy likely promoted microcirculation and lymphatic flow, accelerating nutrient delivery and metabolic waste removal. Red Light Therapy's activation of mitochondrial pathways likely played a role in boosting ATP production and cellular repair. Meanwhile, infrared sauna and cold plunge contrast therapy supported detoxification, reduced inflammation, and enhanced vascular tone. Taken together, the multimodal approach appears to foster a biological environment conducive to regeneration and resilience. These findings are consistent with a growing body of evidence positioning bioimpedance-derived phase angle as a valuable biomarker for health status, aging, and response to therapeutic interventions.

Conclusion
This study provides compelling preliminary evidence that integrative regenerative therapies can significantly enhance cellular function, as demonstrated by substantial increases in bioimpedance phase angle across multiple participants. These results are particularly remarkable given the short duration of the intervention—just four weeks—which typically is not long enough to yield such dramatic improvements in cellular health markers.

The data support the clinical relevance of using phase angle as a biomarker in wellness-focused and longevity-based care. These therapies—ranging from frequency-based modulation to mitochondrial stimulation and detoxification—may play a vital role in improving healthspan and supporting the body's intrinsic repair mechanisms. Future research should aim to expand the sample size, evaluate long-term effects, and incorporate additional objective biomarkers such as inflammatory cytokines, oxidative stress markers, mitochondrial function assays, and epigenetic age testing. A broader dataset could further validate the impact of these therapies and refine protocols for individualized health optimization and age-related decline prevention.

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MEASUREMENT OF CELLULAR VITALITY AND SYSTEMIC INFLAMMATION

By: Matthew Einsohn, RSG

Phase Angle measurements are giving us a way to watch the body rebuild itself — from the inside out. A 9.2% increase in phase angle—from 6.28 to 6.86—in just 4 weeks? That's not just a statistical uptick; it's a substantial leap in cellular health. In the realm of phase angle analysis, even a 0.2 shift is noteworthy. Dr. Leslie Valle-Montoya's preliminary findings underscore the potential of targeted regenerative therapies to effect meaningful biological change in a relatively short time. [1][2]

But here's where it gets even more compelling: phase angle isn't solely a marker of cellular vitality; it's emerging as a non-invasive indicator of systemic inflammation. A study published in Nutrients found that lower phase angle values were significantly associated with higher levels of C-reactive protein (CRP), a well-established marker of inflammation . This association remained significant even after adjusting for factors like age, BMI, and physical activity. [1][2]

Imagine the implications: a simple, non-invasive measurement that provides insights into both cellular integrity and inflammatory status. Now, envision a home-based wellness program—just two sessions a week, totaling eight per month—designed to consistently enhance your cellular health and reduce systemic inflammation.